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Valacyclovir for First Herpes Outbreaks. Valacyclovir for First Herpes Outbreaks. For treatment of cold sores: Adults—2000 milligrams (mg) every 12 hours for one day. For treatment of cold sores: Adults—2000 milligrams (mg) every 12 hours for one day. In HIV‑1−infected patients with a CD4+ cell count greater. In HIV‑1−infected
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